Carnegie Mellon University.
private research university in Pittsburgh, Pennsylvania, United States
Researchers Reveal 3D Genome Folding Linked to Alzheimer's Brain Changes
Multiple studies from CMU, Pitt, and UW connect Alzheimer's pathology to changes in the genome’s 3D architecture, linking genome folding to gene activity with advanced techniques like GAGE-seq and the Hicformer AI model to map these changes in brain tissue. Additional work highlights age-related genome regulation shifts, including microglial turnover and blood-brain barrier cell decline, alongside a mid-stage drug trial where an anti-tau therapy showed potential to slow cognitive decline, underscoring 3D genome remodeling as a core facet of disease and aging beyond amyloid and tau alone.
Health · 6 sources · Jul 23, 2026Read itThe journal
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About Carnegie Mellon University
Carnegie Mellon University (CMU) is a private research university in Pittsburgh, Pennsylvania, United States. The institution was established in 1900 by Andrew Carnegie as the Carnegie Technical Schools. In 1912, it became the Carnegie Institute of Technology and began granting four-year degrees. In 1967, it became Carnegie Mellon University through its merger with the Mellon Institute of Industrial Research, founded in 1913 by Andrew Mellon and Richard B. Mellon and formerly a part of the University of Pittsburgh.
Everything about Carnegie Mellon University →- Country
- United States
- Headquarters
- Pittsburgh
- Inception
- 1900
- Website
- https://cmu.edu