Relationships and children
Quaid has been married four times and has three children. He met his first wife, actress P. J. Soles, on the set of the film Our Winning Season. They were married in 1978 and divorced in 1983.
On February 14, 1991, Quaid married actress Meg Ryan. Quaid and Ryan fell in love during the shooting of their second film together, D.O.A. They have a son, Jack Quaid (born 1992). Quaid and Ryan announced their separation on June 28, 2000, saying they had been separated six weeks by then. Their divorce was finalized in July 2001.
Quaid dated model Shanna Moakler from February to October 2001.
Quaid married Texas real estate agent Kimberly Buffington on July 4, 2004, at his ranch in Paradise Valley, Montana. They have fraternal twins who were born via a surrogate on November 8, 2007, in Santa Monica, California.
On November 18, 2007, hospital staff at Cedars-Sinai Medical Center mistakenly gave Quaid's 10-day-old twins a dosage of heparin (a blood thinner) that was 1,000 times the common dosage for infants. The babies recovered, but Quaid filed a lawsuit against the drug manufacturer, Baxter Healthcare, claiming that packaging for the two doses of heparin are not different enough. In May 2008, the Quaids testified before the United States House Committee on Oversight and Government Reform, asking the U.S. Congress not to preempt the right to sue drug manufacturers for negligence under state law. The incident led Quaid to become a patient-safety advocate, producing a series of documentaries on preventable medical errors that aired on the Discovery Channel, as well as co-authoring a medical-journal article addressing the positive influence of patient stories in motivating change in healthcare. The first documentary, Chasing Zero: Winning the War on Healthcare Harm, aired on the Discovery Channel in 2010, and the second documentary, Surfing the Healthcare Tsunami: Bring Your Best Board, aired on the Discovery Channel in 2012.
Buffington filed for divorce from Quaid in March 2012. Buffington's attorney then withdrew the divorce papers on April 26, 2012. That summer, Quaid and Buffington moved to California. In October 2012, he and Buffington again decided to separate, and Buffington filed for legal separation, seeking joint legal and sole physical custody of the twins. After waiting to establish the required six months of residency in California, Quaid filed for divorce on November 30, 2012, asking for joint legal and physical custody of the children and offering to pay spousal support to Buffington. They then reconciled, and the divorce was dismissed by September 2013. On June 28, 2016, the couple announced in a joint statement that they were divorcing, citing "irreconcilable differences" as the reason, with Buffington asking for full physical custody and joint legal custody. The divorce was finalized on April 27, 2018.
Following his separation from Buffington, Quaid dated model Santa Auzina from July 2016 to 2019.
On October 21, 2019, Quaid confirmed his engagement to Laura Savoie. Their original wedding plans were postponed due to the COVID-19 pandemic, and they married on June 2, 2020, in Santa Barbara. Savoie is a CPA and yoga instructor, 39 years his junior, who shares his Christian faith. Quaid says, "God is in the relationship. I've never had a relationship like that before." Together, they launched the production company Bonniedale Films, based in Nashville, where they live.