21st century
Christie made a brief cameo appearance in the third Harry Potter film, Harry Potter and the Prisoner of Azkaban (2004), playing Madam Rosmerta. Around the same time, she also appeared in two other high-profile films: Wolfgang Petersen's Troy and Marc Forster's Finding Neverland (both 2004), playing mother to Brad Pitt and Kate Winslet, respectively. The latter performance earned Christie a BAFTA nomination as supporting actress in a film.
Christie portrayed the female lead in Away from Her (2006), a film about a long-married Canadian couple coping with the wife's Alzheimer's disease. Based on the Alice Munro short story "The Bear Came Over the Mountain", the movie was the first feature film directed by Christie's sometime co-star, Canadian actress Sarah Polley. She took the role, she said, only because Polley is her friend. Polley has said Christie liked the script but initially turned it down as she was ambivalent about acting. It took several months of persuasion by Polley before Christie finally accepted the role.
In July 2006 she was a member of the jury at the 28th Moscow International Film Festival. Debuting at the Toronto International Film Festival on 11 September 2006 as part of the TIFF's Gala showcase, Away from Her drew rave reviews from the trade press, including The Hollywood Reporter, and the four Toronto dailies. Critics singled out her performances as well as that of her co-star, Canadian actor Gordon Pinsent, and Polley's direction. Christie's performance generated Oscar buzz, leading the distributor, Lions Gate Entertainment, to buy the film at the festival to release the film in 2007 to build momentum during the awards season.
On 5 December 2007, she won the Best Actress Award from the National Board of Review for her performance in Away from Her. She won the Golden Globe Award for Best Actress - Motion Picture Drama, the Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role and the Genie Award for Best Actress for the same film. On 22 January 2008, Christie received her fourth Oscar nomination for Best Performance by an Actress in a Leading Role at the 80th Academy Awards. She appeared at the ceremony wearing a pin calling for the closure of the prison in Guantanamo Bay.
Christie narrated Uncontacted Tribes (2008), a short film for the British-based charity Survival International, featuring previously unseen footage of remote and endangered peoples. She has been a long-standing supporter of the charity, and in February 2008, was named as its first 'Ambassador'. She appeared in a segment of the film, New York, I Love You (also 2008), written by Anthony Minghella, directed by Shekhar Kapur and co-starring Shia LaBeouf, as well as in Glorious 39 (2009), about a British family at the start of World War II.
Christie played a "sexy, bohemian" version of the grandmother role in Catherine Hardwicke's gothic retelling of Red Riding Hood (2011). Her most recent role was in the political thriller The Company You Keep (2012), where she co-starred with Robert Redford and Sam Elliott.
She is a signatory of the Film Workers for Palestine boycott pledge that was published in September 2025.
