Rue or Rué is a surname. Notable people with the surname include:
Gérard Rué (born 1965), French former cyclist
Jean-Baptiste Rué (born 1974), French former rugby union player
Joe Rue (1898-1984), American Major League Baseball umpire
Joseph Rue, French World War II vice-admiral
Lea Rue, stage name of Belgian singer-songwriter Emma Lauwers (born 1993)
Loyal Rue (born 1944), American philosopher and writer
Marcel Rué (born 1926), Monegasque sports shooter
Nancy Rue, American Christian novelist
Rob Rue, American politician
Rosemary Rue (1928-2004), British physician and civil servant
Sander Rue (born 1954), American politician
Sara Rue, American television actress born Sara Schlackman in 1979