2009–2012: Avatar and early momentum
In 2009, Worthington starred in James Cameron-directed science-fiction film Avatar, in which he played the role of Jake Sully, a paraplegic former U.S. Marine who is at the centre of a war between his own species and the indigenous Na'vi people of Pandora. The film was a success, amassing critical acclaim and several accolades. It became (and remains) the highest-grossing film of all time, grossing more than $2.8 billion ($4.1 billion adjusted for inflation) worldwide. It won him the Saturn Award for Best Actor and another AACTA Award.
In November 2010, Worthington told GQ Australia that when he auditioned for the role, he was not told what it was for, which annoyed him. "I was a bit pissed off, and I think that came across. I think Jim saw a spark and liked it because that's Sully's character – a guy who doesn't like to be bullied and a guy who wants to set things right." He later said that Cameron "changed his life" and he will always be grateful to him.
After auditioning for Cameron, Worthington consequently landed the part in 2009's science fiction action film Terminator Salvation, thanks to Cameron's personal recommendation to fellow filmmaker McG. In the film, Worthington co-starred alongside Christian Bale and played Marcus Wright, a human-terminator hybrid. Terminator Salvation was released on May 21, 2009, grossed over $371.4 million, and received mixed reviews.
In early 2010, Worthington appeared in Clash of the Titans, an action fantasy film directed by Louis Leterrier and produced by Metro-Goldwyn-Mayer. Worthington headlined the film. It received generally negative reviews from critics but grossed $493 million worldwide and was the 11th highest-grossing film of 2010. He provided voice work for Captain Alex Mason, the protagonist in the video game Call of Duty: Black Ops. Some gamers criticised Worthington's inability to mask his Australian accent, as in Avatar. In November 2010, The Hollywood Reporter named Worthington as one of the young male actors who are "pushing – or being pushed" into taking over Hollywood. Also in 2010, Forbes named Worthington among Hollywood's highest grossing actors. He was selected as one of the entrants to the Who's Who in Australia 2011 edition.
In 2012, Worthington starred in Wrath of the Titans, the sequel to Clash of the Titans. The film received mostly negative reviews from critics, and although it grossed $302 million at the box office and emerged successful, the film underperformed compared to its predecessor. He reprised his role as Alex Mason in Call of Duty: Black Ops II. Also in 2012, Worthington starred as Nick Cassidy in Man on a Ledge, a suspense-thriller film directed by Asger Leth. Though the film received mixed reviews from critics, Worthington's performance received praise, with The New Zealand Herald describing him as "suitably terrified".