Career expansion (2014–present)
Simran returned to the big screen with a series of unsuccessful films such as Aaha Kalyanam (the Tamil remake of Band Baaja Baaraat) in 2014, Trisha Illana Nayanthara (2015) and Koditta Idangalai Nirappuga (2017). She was widely believed to have made her comeback with 2018's Seemaraja. She followed it up with Petta, which received critical and commercial acclaim. She continued working as a producer, producing and starring in a Hindi music video.
In 2020 she made her streaming debut with Netflix's first Tamil film, Paava Kadhaigal, receiving positive reviews. This was followed up with Mahaan which debuted on Amazon Prime Video after the pandemic meant that a theater release wouldn't be possible.
Simran reunited with R. Madhavan in Rocketry: The Nambi Effect (2022). It was filmed simultaneously in Tamil, Hindi and English languages.
Simran then appeared in the Tamil science fiction action film Captain. And later starred in the Hindi language Gulmohar (2023). She then appeared as the Prime Minister of Pakistan in Tiger 3 (2023). She made a special appearance in a devotional song in Aranmanai 4 (2024). After sharing the screen with Prashanth as the female lead, Simran starred as an antagonist in the Andhadhun remake, Andhagan (2024).
In 2025, Simran appeared as a Sri Lankan Tamil refugee in Abhishan Jeevinth's debut directorial, Tourist Family, opposite M. Sasikumar. While her performance was appraised by critics and audience, the film went on to become India's most profitable film of the year. Her next release, Sabdham was a thriller directed by Arivazhagan Venkatachalam was also a hit at the box office.